1. These then begin meiosis to form the oocyte within the primordial follicle . 2. DNA double-strand breaks accumulate with age in humans and mice in primordial follicles . 3. As women age, double-strand breaks accumulate in the DNA of their primordial follicles . 4. This can take many months in vivo and involves primordial follicle growth and differentiation. 5. Primordial follicles are immature primary oocytes surrounded by a single layer of granulosa cells.6. Babies are born with 1-2 million primordial follicles , and by puberty have around 300, 000. 7. They showed that as women age, double-strand breaks accumulate in the DNA of their primordial follicles . 8. Primordial follicles contain oocytes that are at an intermediate ( prophase I ) stage of meiosis.9. Female infertility by chemotherapy appears to be secondary to premature ovarian failure by loss of primordial follicles . 10. (a ) The maturation of a follicle is shown in a clockwise direction proceeding from the primordial follicles .
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